Increased G+C content of DNA stabilises methyl CpG dinucieotides
نویسندگان
چکیده
منابع مشابه
Dna Sequence Evaluation Dna Sequence Evaluation Gc Content
• A DNA molecule consists of two strands, commonly referred to as top and bottom; positive and negative; or normal and reverse. The contents of one strand form a reverse complement of the other strand. The ”complement” part: A(denine) is always paired with Thymine, while Cytosine is always paired with Guanine. The ”reverse” part: the strand are read in opposite directions: the 5’ end of one str...
متن کاملGC Content Increased at CpG Flanking Positions of Fish Genes Compared with Sea Squirt Orthologs as a Mechanism for Reducing Impact of DNA Methylation
BACKGROUND Fractional DNA methylation in sea squirts evolved to global DNA methylation in fish. The impact of global DNA methylation is reflected by more CpG depletions and/or more A/T to G/C changes at CpG flanking positions due to context-dependent mutations of methylated CpG sites. METHODS AND FINDINGS In this report, we demonstrate that the sea squirt genes have undergone more CpG to TpG/...
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DNA methylation is a key regulatory control route in epigenetics, involving gene silencing and chromosome inactivation. It has been recognized that methyl-CpG binding domain (MBD) proteins play an important role in interpreting the genetic information encoded by methylated DNA (mDNA). Although the function of MBD proteins has attracted considerable attention and is well characterized, the mecha...
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The accumulation of base substitutions (mutations) not subject to natural selection is the neutral mutation rate. Because this rate reflects the in vivo processes involved in maintaining the integrity of genetic information, the factors that affect the neutral mutation rate are of considerable interest. Mammals exhibit two dramatically different neutral mutation rates: the CpG mutation rate, wh...
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We derive theoretical upper and lower bounds on the maximum size of DNA codes of length n with constant GC-content w and minimum Hamming distance d, both with and without the additional constraint that the minimum Hamming distance between any codeword and the reverse-complement of any codeword be at least d. We also explicitly construct codes that are larger than the best previously-published c...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1984
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/12.14.5869